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Pragmatic trials are those that are designed to provide information for the real-world practice of clinical. They are often characterized as a focus on the practical aspects of study design, including the recruitment process and consent, adhering and the use of routinely available equipment.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which used a variety of investigators and had participants from different geographic areas. This kind of heterogeneity, which is essential for pragmatic trials to be reliable and reduce bias in results is also essential. A high degree of heterogeneity, however, can cause problems with the trial design.
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Mobile compatibility
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Legality
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The purpose of pragmatic trials is to replicate real-life scenarios and to achieve the highest level of validity externally. Usually, they are ordered by policymakers and practitioners to help guide their decisions. They can also be used to assess the cause-effect relationship of an intervention with its outcomes. However, they should not be used to replace the need for explanation studies.
The pragmatism concept is controversial, and there are questions about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 proposed the distinction between explanation studies, which prove a physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in the decision-making process for policy and practice. They also proposed an approach to pragmatic trials, dubbed PRECIS.2 This tool sought to define the characteristics of a pragmatic trial, including the recruitment process, the design and implementation of the intervention, and monitoring.
There is a growing increase in the number pragmatic trials that have been published. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to controlled trials that are randomized (RCTs) produced 34 articles, as shown in red in Figure 2. This is an indication that the health science community is becoming more acquaint to the issue of pragmatic thinking. It is important to note that the majority of these studies were conducted in primary-care settings.